The Liu lab has broad interests in exploring the molecular mechanisms that govern the maintenance of cellular homeostasis. Currently, we focus on two major directions: mitochondrial stress response and nutrient sensing mechanisms.

Using a variety of systems including C. elegans, mammalian cell culture and hard-core biochemistry, the lab seeks to understand the molecular basis of mitochondrial stress response pathways that sense mitochondrial dysfunction and activate protective programs. The lab also seeks to understand how organisms sense and respond to changes in nutrient availability. Understanding these fundamental processes may provide insights to the therapeutics of many diseases, including obesity, diabetes, and age-related disorders.